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HIV PrEP, Preventive Medication, 2019

* Indicates an old grade definition


Recommendations: Preventive Medication for HIV PrEP

  • HIV PrEP: Preventive Medications --Persons at high risk of HIV acquisition
    Grade: A
    Specific Recommendations:

    The USPSTF recommends that clinicians offer pre-exposure prophylaxis (PrEP) with effective antiretroviral therapy to persons who are at high risk of HIV acquisition.

    See the Clinical Considerations section for information about identification of persons at high risk and selection of effective antiretroviral therapy.

    Frequency of Service:

    No Frequency of Service information currently available.

    Risk Factor Information:

    Persons at risk of HIV infection include men who have sex with men, persons at risk via heterosexual contact, and persons who inject drugs. Within these groups, certain risk factors or behaviors (outlined below) can place persons at high risk of HIV infection.

    Men who have sex with men, are sexually active, and have 1 of the following characteristics:

    • A serodiscordant sex partner (ie, in a sexual relationship with a partner living with HIV)
    • Inconsistent use of condoms during receptive or insertive anal sex
    • An STI with syphilis, gonorrhea, or chlamydia within the past 6 months

    Heterosexually active women and men who have 1 of the following characteristics:

    • A serodiscordant sex partner (ie, in a sexual relationship with a partner living with HIV)
    • Inconsistent use of condoms during sex with a partner whose HIV status is unknown and who is at high risk (eg, a person who injects drugs or a man who has sex with men and women)
    • An STI with syphilis or gonorrhea within the past 6 months

    Persons who inject drugs and have 1 of the following characteristics:

    • Shared use of drug injection equipment
    • Risk of sexual acquisition of HIV (see above)

    Persons who engage in transactional sex, persons who are trafficked for sex work, men who have sex with men and women, and transgender women and men who are sexually active can be at high risk of HIV infection, and should be considered for PrEP based on the criteria outlined above.”

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