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Syphilis Infection in Nonpregnant Adults and Adolescents, Screening, 2016

* Indicates an old grade definition


Recommendations: Screening for Syphilis Infection in Nonpregnant Adults and Adolescents

  • Syphilis: Screening --Asymptomatic, nonpregnant adults and adolescents who are at increased risk for syphilis infection
    Grade: A
    Specific Recommendations:

    The USPSTF recommends screening for syphilis infection in persons who are at increased risk for infection.

    Frequency of Service:

    The optimal screening frequency for persons who are at increased risk for syphilis infection is not well established. Men who have sex with men or persons living with HIV may benefit from more frequent screening. Initial studies suggest that detection of syphilis infection in MSM or persons living with HIV improves when screening is performed every 3 months compared with annually.7

    Risk Factor Information:

    Based on 2014 surveillance data,1 men who have sex with men (MSM) and men and women living with HIV have the highest risk for syphilis infection.  When deciding which other persons to screen for syphilis, clinicians should be aware of the prevalence of infection in the communities they serve, as well as other sociodemographic factors that may be associated with increased risk of syphilis infection. Factors associated with increased prevalence that clinicians should consider include history of incarceration, history of commercial sex work, certain racial/ethnic groups, and being a male younger than 29 years, as well as regional variations that are well described. Refer to clinical considerations of the recommendation statement.

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